期刊
NUTRIENTS
卷 13, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/nu13051419
关键词
omega-3; erythrocyte; plasma; whole blood; dose response
资金
- Australian Research Council [LP0562017]
- Nu-Mega Ingredients
- APA-I PhD Scholarship
- Australian Research Council [LP0562017] Funding Source: Australian Research Council
The study compared the sensitivity of fingertip whole blood to reflect habitual dietary and dose-dependent supplemental omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) intake in premenopausal women with venous erythrocytes and plasma fatty acids. The results showed that fingertip whole blood, erythrocytes, and plasma were all similarly effective in reflecting dietary n-3 LCPUFA intake and dose-dependent changes after supplementation. Fingertip whole blood can be considered as an effective alternative biomarker for assessing n-3 LCPUFA intake in premenopausal women.
The sensitivity of fingertip whole blood to reflect habitual dietary and dose-dependent supplemental omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) intake in premenopausal women was compared to that of venous erythrocytes and plasma fatty acids. Samples were obtained from women in a randomised, double-blind, placebo-controlled trial in which premenopausal women (n = 53) were supplemented with DHA-rich tuna oil capsules and/or placebo (Sunola oil) capsules (6 capsules per day) for 8 weeks to achieve doses of either 0, 0.35, 0.7 or 1.05 g/day n-3 LCPUFA. All blood biomarkers were very similar in their ability to reflect dietary n-3 LCPUFA intake (r = 0.38-0.46 for EPA and DHA intake), and in their dose-dependent increases in n-3 LCPUFA levels after supplementation (R-2 = 0.41-0.51 for dose effect on biomarker EPA and DHA levels (mol %)). Fingertip whole blood is an effective alternative to erythrocytes and plasma as a biomarker n-3 LCPUFA intake in premenopausal women.
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