4.7 Article

Characterization of Gut Microbiome in Korean Patients with Metabolic Associated Fatty Liver Disease

期刊

NUTRIENTS
卷 13, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/nu13031013

关键词

metabolic associated fatty liver disease; non-alcoholic fatty liver disease; gastrointestinal microbiome; short-chain fatty acids; butyrate; ethanol

资金

  1. National Research Foundation of Korea (NRF) - Korea government (Ministry of Science and ICT) [NRF-2016R1C1B2015463, NRF-2019R1C1C1007729]
  2. National Research Foundation of Korea (NRF) - Korea government (Ministry of Education) [2020R1I1A1A01075559]
  3. BK21 FOUR Project
  4. Future Medicine 20*30 Project of Samsung Medical Center [SMX1210771]
  5. National Research Foundation of Korea [2020R1I1A1A01075559] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study found that MAFLD patients had lower gut microbiome diversity and significant differences at phylum, class, family, and genus levels compared to healthy controls, such as increased abundance of Proteobacteria, Enterobactereriaceae, Citrobacter, and decreased abundance of Faecalibacterium. Additionally, butyrate-producing bacteria were decreased and ethanol-producing bacteria were increased in MAFLD patients. These findings suggest potential targets for therapeutic intervention in MAFLD.
Metabolic associated fatty liver disease (MAFLD) is a new concept where the presence of both fatty liver and metabolic abnormality are necessary for diagnosis. Several studies have reported that altered gut microbiome is closely associated with metabolic diseases and non-alcoholic fatty liver disease. However, the studies on MAFLD population are scarce. This prospective study aimed to identify differences in gut microbiome between patients with MAFLD and healthy controls in Korean population. In this study, patients with MAFLD and age, sex-matched healthy controls were included, and their stool samples were collected. Taxonomic composition of gut microbiota was analyzed using 16S ribosomal ribonucleic acid pyrosequencing. Twenty-two MAFLD patients and 44 healthy controls were included. Taxonomic diversity was lower in patients with MAFLD in the aspect of alpha and beta diversity. The differences were also found at phylum, class, family, and genus levels between the two groups. Phylum Proteobacteria, family Enterobactereriaceae, genus Citrobacter abundance was significantly increased and genus Faecalibacterium was significantly decreased in patients with MAFLD. In addition, butyrate-producing bacteria were decreased and ethanol-producing bacteria were increased in patients with MAFLD. The composition of gut microbiome was different between MAFLD and healthy controls in Korean population. This could offer potential targets for therapeutic intervention in MAFLD.

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