期刊
NUTRIENTS
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu13031022
关键词
dipropyl polysulfides; ConA hepatitis; anti-inflammatory activity; hepatoprotective effects
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [ON175069, ON172018, 451-03-9/2021-14/200026, 451-03-9/2021-14/200168]
- Serbian bilateral project with PR China [06/2018]
- Faculty of Medical Sciences, University of Kragujevac [MP 01/19, JP 22/19]
The study synthesized a mixture of DPPS and tested its biological activity in acute hepatitis, showing that DPPS pretreatment significantly reduced liver inflammation and injury, indicating potential therapeutic usage of DPPS in inflammatory liver diseases.
The main biologically active components of plants belonging to the genus Allium, responsible for their biological activities, including anti-inflammatory, antioxidant and immunomodulatory, are organosulfur compounds. The aim of this study was to synthetize the mixture of dipropyl polysulfides (DPPS) and to test their biological activity in acute hepatitis. C57BL/6 mice were administered orally with DPPS 6 h before intravenous injection of Concanavalin A (ConA). Liver inflammation, necrosis and hepatocytes apoptosis were determined by histological analyses. Cytokines in liver tissue were determined by ELISA, expression of adhesive molecules and enzymes by RT PCR, while liver mononuclear cells were analyzed by flow cytometry. DPPS pretreatment significantly attenuated liver inflammation and injury, as evidenced by biochemical and histopathological observations. In DPPS-pretreated mice, messenger RNA levels of adhesion molecules and NADPH oxidase complex were significantly reduced, while the expression of SOD enzymes was enhanced. DPPS pretreatment decreased protein level of inflammatory cytokines and increased percentage of T regulatory cells in the livers of ConA mice. DPPS showed hepatoprotective effects in ConA-induced hepatitis, characterized by attenuation of inflammation and affection of Th17/Treg balance in favor of T regulatory cells and implicating potential therapeutic usage of DPPS mixture in inflammatory liver diseases.
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