Copper and Nickel Microsensors Produced by Selective Laser Reductive Sintering for Non-Enzymatic Glucose Detection

In this work, the method of selective laser reductive sintering was used to fabricate the sensor-active copper and nickel microstructures on the surface of glass-ceramics suitable for non-enzymatic detection of glucose. The calculated sensitivities for these microsensors are 1110 and 2080 mu A mM(-1)center dot cm(-2) for copper and nickel, respectively. Linear regime of enzymeless glucose sensing is provided between 0.003 and 3 mM for copper and between 0.01 and 3 mM for nickel. Limits of glucose detection for these manufactured micropatterns are equal to 0.91 and 2.1 mu M for copper and nickel, respectively. In addition, the fabricated materials demonstrate rather good selectivity, long-term stability and reproducibility.

Automated summary

Selective laser reductive sintering was used in this study to fabricate sensor-active copper and nickel microstructures for non-enzymatic detection of glucose on glass-ceramic surfaces. The microsensors exhibited calculated sensitivities of 1110 and 2080 mu A mM(-1)center dot cm(-2) for copper and nickel, respectively. The fabricated micropatterns had limits of glucose detection of 0.91 and 2.1 mu M for copper and nickel, and demonstrated good selectivity, long-term stability, and reproducibility.