期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 20, 期 10, 页码 3227-3235出版社
WILEY
DOI: 10.1111/jocd.14089
关键词
androgenetic alopecia; hair follicle; hair loss; platelet‐ rich plasma
类别
资金
- National Natural Science Foundation of China [81772104, 81701929, 81971889, 81902013]
- Natural Science Foundation of Guangdong Province [2017A030310120]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515012170]
- Science and Technology Program of Guangzhou [201904010480]
- Medical Scientific Research Foundation of Guangdong Province [C2019112]
The study elucidated the specific molecular mechanism of PRP action on hair growth and confirmed the therapeutic efficacy and safety of PRP in Chinese AGA patients.Results showed that PRP treatment boosted hair regrowth, accelerated hair cycling in mice, and PRP group demonstrated significantly improved hair count, density, diameter, and anagen hair ratio compared to control side at 6 months.
Background Platelet rich plasma (PRP) has been accepted as a potential therapy for treating androgenetic alopecia (AGA). Objective To fully clarify the underling molecular mechanisms of PRP action on hair growth and promote its clinical applications. Methods In this study, we used mice models and protein biochip to explore the specific mechanisms of PRP regulating hair growth. Then, we performed a randomized, placebo-controlled, double-blind, half-head study of 52 AGA patients to verify the therapeutic efficacy of PRP in Chinese AGA patients. Results The results confirmed that PRP treatment boosted hair regrowth, accelerated hair cycling, and the effect sustained for more than one hair cycle in mice. Protein biochip evaluation confirmed remarkably upregulated beta-Catenin, PDGF, and AKT signaling and repressed p53 signaling in PRP injection group. Clinically, mean hair count, density, diameter, and anagen hair ratio in PRP group showed a significant improvement at 6 month comparing to control side. Conclusions Overall, we elucidated the specific molecular mechanism of PRP action on hair growth and proved the therapeutic efficacy and safety of PRP in Chinese AGA patients.
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