期刊
GREEN CHEMISTRY LETTERS AND REVIEWS
卷 14, 期 2, 页码 402-412出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17518253.2021.1923824
关键词
NiO nanoparticles; Gum Arabic; photocatalytic degradation; cytotoxicity; antibacterial
资金
- Mashhad University of Medical Sciences [992280]
In this study, NiO-NPs were synthesized using a sol-gel method with Arabic gum (GA) as a stabilizing agent, and their structural, optical, magnetic properties, antimicrobial activity, and photocatalytic efficiency were investigated. The results demonstrated that NiO-NPs exhibited strong antimicrobial activity against both Gram-positive and Gram-negative bacteria, and achieved a photocatalytic degradation efficiency of about 80%.
In the current paper, NiO-NPs were synthesized through a sol-gel method by the usage of a biocompatible polymer known as Arabic gum (GA) as a stabilizing agent. The structural, optical, and magnetic properties of the obtained product was investigated by the application of TGA/DTA, FT-IR, UV-Vis, XRD, FESEM/EDX, and VSM analyzes. The FESEM images of NiO-NPs displayed its spherical shape and average size of about 59 nm. The antimicrobial activity of NiO-NPs was investigated against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis and Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa. The achieved findings indicated that all of the bacterial resistance was attributed to NiO-NPs, except for the case of Bacillus subtilis bacteria that did not grow at the concentration of 10 mM. We also evaluated the photocatalytic activity of nanoparticles in regards to the MB degradation and observed a photocatalytic degradation efficiency of about 80% throughout the results. The cytotoxicity of NiO-NPs has evaluated towards the cancer U87MG cell and normal Nervous Neurospheres (NCs) cells lines by means of MTT method. Detailed in vitro biological activities revealed the significant therapeutic potential of NiO-NPs. This product was able to exhibit potent cytotoxicity against U87MG cancer cells (IC50: 37.84 mu g mL(-1)). [GRAPHICS]
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