期刊
GREEN CHEMISTRY LETTERS AND REVIEWS
卷 14, 期 2, 页码 393-401出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17518253.2021.1921285
关键词
Diperiodatoargentate(III); mitoxantrone Mitoxantrone; Chemiluminescence; Human serum; Reaction mechanism
资金
- Training Program of Young Key Teachers in Colleges and Universities in Henan Province [2018GGJS008]
The Chemiluminescence (CL) method combined with the flow-injection (FI) technique is an attractive alternative for pharmaceutical analysis. A highly sensitive flow injection CL method was developed for the determination of mitoxantrone, with a linear range of 8.0 x 10(-10)-5.0 x 10(-7) g/mL and a detection limit of 1.9 x 10(-10) g/mL. The method showed good reproducibility and was successfully applied to pharmaceutical preparation and serum samples.
Chemiluminescence (CL) method, combined with the flow-injection (FI) technique, is an attractive alternative for pharmaceutical analysis. In this paper, a CL reaction between diperiodatoargentate(III) (DPA) and mitoxantrone (MTX) was observed. A strong CL signal was generated during the reaction of mitoxantrone with DPA in an alkaline medium. Thus a highly sensitive flow injection CL method was developed for the determination of mitoxantrone. Optimized experimental conditions were investigated in detail. Under the optimum conditions, the relative CL intensity was linear with the mitoxantrone concentration in the range of 8.0 x 10(-10)-5.0 x 10(-7) g/mL with a correlation coefficient of 0.9994 and the detection limit was 1.9 x 10(-10) g/mL. The proposed method had good reproducibility with a relative standard deviation of 1.5% (n = 11) for 1.0 x 10(-7) g/mL mitoxantrone. The highly sensitive method was successfully applied to the determination of mitoxantrone in pharmaceutical preparation and serum samples with satisfactory results. The possible CL reaction mechanism was also discussed briefly. [GRAPHICS] .
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