期刊
EUROINTERVENTION
卷 16, 期 17, 页码 1447-1454出版社
EUROPA EDITION
DOI: 10.4244/EIJ-D-20-01008
关键词
mitral regurgitation; mitral valve disease; mitral valve repair; prior percutaneous intervention
This study evaluated the survival outcomes following percutaneous procedures and surgery after unsuccessful TMVR interventions for different aetiologies. It found that reclipping is a suitable treatment option for symptomatic patients with secondary mitral regurgitation, while surgery should be favored for primary mitral regurgitation patients. Patients with atrial fibrillation, prior open heart surgery, and chronic obstructive pulmonary disease are at higher risk of reduced survival following reinterventions.
Aims: Failure of transcatheter mitral valve repair (fTMVR) therapy has a decisive prognostic influence, and complex retreatment is of higher risk. The aim of this analysis was to evaluate the survival outcome following percutaneous procedures and surgery after unsuccessful TMVR interventions for different aetiologies. Methods and results: Of 824 consecutive patients who had been treated with the MitraClip device at our institution, between September 2009 and May 2019, 63 (7.6%) symptomatic patients with therapy failure and persistent or recurrent mitral regurgitation (MR) underwent reinterventions. An outcome analysis for primary (PMR) and secondary mitral regurgitation (SMR) and subsequent percutaneous versus surgical treatment was carried out. MitraClip reinterventions were performed in 36 patients (57.1%; n=26 SMR, n=10 PMR), while 27 (42.9%; n=13 SMR, n=14 PMR) underwent open heart surgery. Surgical patients with PMR showed lower mortality than patients with SMR (p<0.0001) and ReClip patients with PMR (p=0.073). Atrial fibrillation (HR 2.915, 95% CI: [1.311, 6.480]), prior open heart surgery (2.820 [1.215, 6.544]) and chronic obstructive pulmonary disease (2.506 [1.099, 5.714]) increased the risk of death. The level of post-interventional MR had no relevant impact on survival. Conclusions: We conclude that, after SMR and failed TMVR, reclipping is an appropriate treatment option for symptomatic patients. For PMR patients, surgery must be favoured over a reclipping procedure. However, patients with atrial fibrillation, prior open heart surgery and chronic obstructive pulmonary disease are at risk of reduced survival after reinterventions.
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