4.7 Article

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

Sumiko Takao et al.

Summary: The dysregulated gene expression in human cancers is often attributed to aberrant assembly of transcriptional co-activator complexes, as demonstrated in the case of acute myeloid leukemia (AML) subtypes. Targeted interference with MYB:CBP/P300 complexes can induce myeloid differentiation and apoptosis, providing a unified mechanism for oncogenic gene expression in AML. This study establishes a promising strategy for pharmacologic reprogramming and therapeutic targeting in diverse leukemias and potentially other human cancers.
Article Biochemical Research Methods

Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

Georg Michlits et al.

NATURE METHODS (2020)

Letter Biotechnology & Applied Microbiology

CRISPResso2 provides accurate and rapid genome editing sequence analysis

Kendell Clement et al.

NATURE BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Profiling of Pluripotency Factors in Single Cells and Early Embryos

Sarah J. Hainer et al.

Review Cell Biology

The role of noncoding mutations in blood cancers

Sunniyat Rahman et al.

DISEASE MODELS & MECHANISMS (2019)

Article Oncology

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

V. Walf-Vorderwulbecke et al.

LEUKEMIA (2018)

Article Biochemistry & Molecular Biology

ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation

Ino D. Karemaker et al.

EMBO REPORTS (2018)

Article Biochemical Research Methods

Targeted in situ genome-wide profiling with high efficiency for low cell numbers

Peter J. Skene et al.

NATURE PROTOCOLS (2018)

Article Multidisciplinary Sciences

Peptidomimetic blockade of MYB in acute myeloid leukemia

Kavitha Ramaswamy et al.

NATURE COMMUNICATIONS (2018)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

Nuala A. O'Leary et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Oncology

Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells

Sagar Uttarkar et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Genetics & Heredity

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

Yotam Drier et al.

NATURE GENETICS (2016)

Review Genetics & Heredity

Role of non-coding sequence variants in cancer

Ekta Khurana et al.

NATURE REVIEWS GENETICS (2016)

Article Multidisciplinary Sciences

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Denes Hnisz et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

fluff: exploratory analysis and visualization of high-throughput sequencing data

Georgios Georgiou et al.

Article Multidisciplinary Sciences

Cis-regulatory mechanisms governing stem and progenitor cell transitions

Kirby D. Johnson et al.

SCIENCE ADVANCES (2015)

Article Biochemistry & Molecular Biology

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

Matthew T. Weirauch et al.

Article Multidisciplinary Sciences

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Paul A. Northcott et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

A NOTCH 1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

Daniel Herranz et al.

NATURE MEDICINE (2014)

Article Biotechnology & Applied Microbiology

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li et al.

GENOME BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Jakob Loven et al.

Review Biochemistry & Molecular Biology

Lessons from the Cancer Genome

Levi A. Garraway et al.

Review Multidisciplinary Sciences

Cancer Genome Landscapes

Bert Vogelstein et al.

SCIENCE (2013)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

Matthew T. Maurano et al.

SCIENCE (2012)

Article Biochemical Research Methods

BigWig and BigBed: enabling browsing of large distributed datasets

W. J. Kent et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Article Biotechnology & Applied Microbiology

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead et al.

GENOME BIOLOGY (2009)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Review Oncology

MYB function in normal and cancer cells

Robert G. Ramsay et al.

NATURE REVIEWS CANCER (2008)

Article Biochemistry & Molecular Biology

Distinct functions of dispersed GATA factor complexes at an endogenous gene locus

Jeffrey A. Grass et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Cell Biology

c-Myb and p300 regulate stem cell proliferation an hematopoietic differentiation

ML Sandberg et al.

DEVELOPMENTAL CELL (2005)

Article Multidisciplinary Sciences

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction

JL Best et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The UCSC Table Browser data retrieval tool

D Karolchik et al.

NUCLEIC ACIDS RESEARCH (2004)