CAR T-cell therapy in multiple myeloma: more room for improvement

The emergence of various novel therapies over the last decade has changed the therapeutic landscape for multiple myeloma. While the clinical outcomes have improved significantly, the disease remains incurable, typically in patients with relapsed and refractory disease. Chimeric antigen receptor (CAR) T-cell therapies have achieved remarkable clinical success in B-cell malignancies. This scope of research has more recently been extended to the field of myeloma. While B-cell maturation antigen (BCMA) is currently the most well-studied CAR T antigen target in this disease, many other antigens are also undergoing intensive investigations. Some studies have shown encouraging results, whereas some others have demonstrated unfavorable results due to reasons such as toxicity and lack of clinical efficacy. Herein, we provide an overview of CAR T-cell therapies in myeloma, highlighted what has been achieved over the past decade, including the latest updates from ASH 2020 and discussed some of the challenges faced. Considering the current hits and misses of CAR T therapies, we provide a comprehensive analysis on the current manufacturing technologies, and deliberate on the future of CAR T-cell domain in MM.

Automated summary

Over the past decade, the emergence of various novel therapies has significantly impacted the therapeutic landscape for multiple myeloma. CAR T-cell therapies have shown remarkable success in B-cell malignancies and are now being further researched and applied in the field of myeloma. However, challenges such as toxicity and lack of clinical efficacy still exist, prompting a comprehensive analysis of manufacturing technologies and the future of CAR T-cell therapies in multiple myeloma.