期刊
BIOMEDICAL OPTICS EXPRESS
卷 12, 期 5, 页码 2734-2743出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.420828
关键词
-
资金
- National Research Foundation of Korea [2016R1A2B301306115]
- PiQuant Inc.
Silver-gold alloy nanohole arrays demonstrate enhanced refractive index sensitivity and long-term stability for ultra-sensitive plasmonic label-free detection of Escherichia coli, providing a new outlook for widely applicable biosensing and bio-medical applications.
Alloy nanostructures unveil extraordinary plasmonic phenomena that supersede the mono-metallic counterparts. Here we report silver-gold (Ag-Au) alloy nanohole arrays (alpha NHA) for ultra-sensitive plasmonic label-free detection of Escherichia Coli (E. coli). Large-area alpha-NHA were fabricated by using nanoimprint lithography and concurrent thermal evaporation of Ag and Au. The completely miscible Ag-Au alloy exhibits an entirely different dielectric function in the near infra-red wavelength range compared to mono-metallic Ag or Au. The alpha-NHA demonstrate substantially enhanced refractive index sensitivity of 387 nm/RIU, surpassing those of Ag or Au mono-metallic nanohole arrays by approximately 40%. Moreover, the alpha-NHA provide highly durable material stability to corrosion and oxidation during over one-month observation. The ultra-sensitive alpha-NHA allow the label-free detection of E. coil in various concentration levels ranging from 10(3) to 10(8) cfu/ml with a calculated limit of detection of 59 cfu/ml. This novel alloy plasmonic material provides a new outlook for widely applicable biosensing and blo-medical applications. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据