Ligand-Controlled Ni(0)-Al(III) Bimetal-Catalyzed C3-H Alkenylation of 2-Pyridones by Reversing Conventional Selectivity

Conventional C-H alkenylation with alkynes via low-valent transition-metal catalysis occurs at the C6 or C4 position of 2-pyridone with electron-deficient C-H bonds. A bifunctional ligand-bonded Ni-Al bimetallic catalyst resulted in a reversed selectivity, providing a series of C3-alkenylated 2-pyridones in up to 99% yields.

Automated summary

Conventional C-H alkenylation of 2-pyridone with electron-deficient C-H bonds typically occurs at the C6 or C4 position using low-valent transition-metal catalysis. However, a Ni-Al bimetallic catalyst with a bifunctional ligand resulted in a reversed selectivity, providing high yields of C3-alkenylated 2-pyridones.