期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-22351-5
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资金
- German Center for Neurodegenerative Diseases (DZNE) by the Federal Ministry of Education and Research (BMBF)
- Ministry of Culture and Science of the German State of North Rhine-Westphalia
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [EXC 2151 - 390873048]
- Federal Ministry of Health (BMG)
The study conducted in Bonn, Germany examined the seroprevalence and temporal course of SARS-CoV-2 neutralizing antibodies, revealing a low prevalence (<1%) and a relatively rapid waning of neutralizing antibodies within a few months after the first epidemic wave. Only about 20% of individuals with positive neutralizing antibodies lost them within five months. Further population-based studies are needed to understand immunity levels and antibody dynamics.
To estimate the seroprevalence and temporal course of SARS-CoV-2 neutralizing antibodies, we embedded a multi-tiered seroprevalence survey within an ongoing community-based cohort study in Bonn, Germany. We first assessed anti-SARS-CoV-2 immunoglobulin G levels with an immunoassay, followed by confirmatory testing of borderline and positive test results with a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (PRNT). Those with a borderline or positive immunoassay result were retested after 4 to 5 months. At baseline, 4771 persons participated (88% response rate). Between April 24(th) and June 30(th), 2020, seroprevalence was 0.97% (95% CI: 0.72-1.30) by immunoassay and 0.36% (95% CI: 0.21-0.61) when considering only those with two additional positive confirmatory tests. Importantly, about 20% of PRNT+ individuals lost their neutralizing antibodies within five months. Here, we show that neutralizing antibodies are detectable in only one third of those with a positive immunoassay result, and wane relatively quickly. Population-based studies of SARS-CoV-2 seroprevalence are needed to understand levels of immunity and antibody dynamics. Here, the authors show that the seroprevalence in Bonn, Germany was low (<1%) following the first epidemic wave, and that neutralising antibodies waned within a few months.
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