4.8 Article

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

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Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

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Summary: This study demonstrates that mitochondrial membrane potential (MMP) plays a crucial role in old hematopoietic stem cells (HSCs) and its pharmacological manipulation can alter transcriptional programs with beneficial consequences for function. Enhancing MMP in old HSCs can increase engraftment potential upon transplantation and reverse myeloid-biased peripheral blood output.

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