期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41467-021-22535-z
关键词
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资金
- AIRC IG [14414, 21636]
- AIRC [21636]
- ICGEB fellowship
- Japan Society for the Promotion of Science (JSPS) [15H05785]
- AIRC Special Program Molecular Clinical Oncology 5 per mille [10016, 22759]
- Italian Epigenomics Flagship Project (Epigen)
- Fondazione Umberto Veronesi (Post-Doctoral Fellowship 2020)
Loss of TIM4 expression in lung tumor-associated cDC1 leads to inefficient uptake of cell-associated antigens and reduced activation of CD8+ T cells in advanced lung tumors. This contributes to immune surveillance and anti-tumor immune responses.
Acquisition of cell-associated tumor antigens by type 1 dendritic cells (cDC1) is essential to induce and sustain tumor specific CD8(+) T cells via cross-presentation. Here we show that capture and engulfment of cell associated antigens by tissue resident lung cDC1 is inhibited during progression of mouse lung tumors. Mechanistically, loss of phagocytosis is linked to tumor-mediated downregulation of the phosphatidylserine receptor TIM4, that is highly expressed in normal lung resident cDC1. TIM4 receptor blockade and conditional cDC1 deletion impair activation of tumor specific CD8(+) T cells and promote tumor progression. In human lung adenocarcinomas, TIM4 transcripts increase the prognostic value of a cDC1 signature and predict responses to PD-1 treatment. Thus, TIM4 on lung resident cDC1 contributes to immune surveillance and its expression is suppressed in advanced tumors. Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8+T cell activation in advanced lung tumors.
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