期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41467-021-22292-z
关键词
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资金
- European Research Council ERC [692640]
- Deutsche Forschungsgemeinschaft (DFG)
Methods enabling site-selective acylation of sp3 C-H bonds in complex organic molecules are not well explored. Here, the authors present a direct and site-selective acylation of benzylic C-H bonds through the combination of N-heterocyclic carbene (NHC) and photoredox catalysis, offering options for preparing benzyl aryl ketones.
Methods that enable site selective acylation of sp(3) C-H bonds in complex organic molecules are not well explored, particularly if compared with analogous transformations of aromatic and vinylic sp(2) C-H bonds. We report herein a direct acylation of benzylic C-H bonds by merging N-heterocyclic carbene (NHC) and photoredox catalysis. The method allows the preparation of a diverse range of benzylic ketones with good functional group tolerance under mild conditions. The reaction can be used to install acyl groups on highly functionalized natural product derived compounds and the C-H functionalization works with excellent site selectivity. The combination of NHC and photoredox catalysis offers options in preparing benzyl aryl ketones. Direct acylation of sp3 C-H bonds in complex organic molecules is not well established compared to that of sp2 C-H bonds. Here, the authors report the combination of N-heterocyclic carbene (NHC) and photoredox catalysis for the direct and site-selective acylation of benzylic C-H bonds.
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