Supervised dimensionality reduction for big data

To solve key biomedical problems, experimentalists now routinely measure millions or billions of features (dimensions) per sample, with the hope that data science techniques will be able to build accurate data-driven inferences. Because sample sizes are typically orders of magnitude smaller than the dimensionality of these data, valid inferences require finding a low-dimensional representation that preserves the discriminating information (e.g., whether the individual suffers from a particular disease). There is a lack of interpretable supervised dimensionality reduction methods that scale to millions of dimensions with strong statistical theoretical guarantees. We introduce an approach to extending principal components analysis by incorporating class-conditional moment estimates into the low-dimensional projection. The simplest version, Linear Optimal Low-rank projection, incorporates the class-conditional means. We prove, and substantiate with both synthetic and real data benchmarks, that Linear Optimal Low-Rank Projection and its generalizations lead to improved data representations for subsequent classification, while maintaining computational efficiency and scalability. Using multiple brain imaging datasets consisting of more than 150 million features, and several genomics datasets with more than 500,000 features, Linear Optimal Low-Rank Projection outperforms other scalable linear dimensionality reduction techniques in terms of accuracy, while only requiring a few minutes on a standard desktop computer. Biomedical measurements usually generate high-dimensional data where individual samples are classified in several categories. Vogelstein et al. propose a supervised dimensionality reduction method which estimates the low-dimensional data projection for classification and prediction in big datasets.

Automated summary

Researchers have introduced a method that combines class-conditional moment estimates into low-dimensional projection, aiming to achieve more accurate dimensionality reduction for high-dimensional biomedical data for subsequent classification. The method has been validated on datasets with varying numbers of features, demonstrating improved accuracy and computational efficiency.