期刊
ONCOLOGY LETTERS
卷 21, 期 6, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.12743
关键词
Newcastle disease virus; A549; microRNA; lung cancer; oncolysis
类别
资金
- Natural Science Foundation of Guangxi, China [2018GXNSFDA281043]
- National Natural Science Foundation of China [81960511]
- Guangxi First-class Discipline Project for Basic and Medicine Sciences
The study revealed that miR-204 plays a critical role in NDV-induced oncolysis in lung cancer cells by regulating the Caspase-3 and Bax pathway. This suggests the potential of utilizing miRs to enhance the oncolytic potency of NDV, with miR-204 identified as a tumor suppressor in NDV-induced oncolysis of lung cancer cells.
Tumor development and progression are closely associated with various microRNAs (miRNAs/miRs). We have previously shown that Newcastle disease virus (NDV) strain 7793 induces oncolysis in lung cancer. However, how NDV exerts its oncolytic effect on lung cancer remains to be investigated. The present study assessed the role of miR-204 in the NDV-induced oncolysis of lung cancer A549 cells by oncolysis induction in vitro. miR-204 was significantly upregulated in NDV-treated A549 cells. Overexpression or inhibition of miR-204 was significantly associated with NDV-induced oncolysis in A549 cells. Caspase-3 and Bax, major regulators of the apoptosis pathway, were regulated by miR-204, and the association between caspase-3-related apoptosis and miR-204 was identified in NDV-mediated oncolysis. These data demonstrated that miR-204 as a tumor suppressor played a role in NDV-induced oncolysis in lung cancer cells. The present study demonstrates the potential of strategies using miRs to improve oncolytic NDV potency, and highlights miR-204 as a tumor suppressor in NDV-induced oncolysis of lung cancer cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据