LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis

Aim: Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Materials & methods: Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. Results: We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Conclusion: Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.

Automated summary

The study constructed a ceRNA network associated with renal fibrosis, revealing that Gas5 may regulate extracellular Fn1 deposition by targeting the transcription factor Creb5. This provides a theoretical basis for the ceRNA regulation mechanism of Gas5 and offers experimental evidence supporting Gas5 targeting in the treatment of renal fibrosis.