期刊
JOURNAL OF FUNCTIONAL FOODS
卷 82, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104431
关键词
Microbiota; Probiotics; Mental disorders; Depression; Crohn's disease
资金
- National Nature Science Foundation of China [81918293]
This study evaluated the impact of probiotics on cognitive reactivity to sad mood in patients with Crohn's disease through a crossover experiment. The results indicated that probiotics have the tendency to improve cognitive reactivity to sad mood in these patients, but the effect may vary at different treatment stages.
Background: Gut microbiota could modulate brain functions and consequent behavior through gut-brain axis. We evaluated the impact of intestinal flora using probiotics in patients with Crohn's disease (CD) on cognitive reactivity to sad mood. Method: Patients in Group 1 received multiple probiotics followed by Chamomile capsules. Patients in Group 2 received Chamomile capsules followed by multiple probiotics. Patients accomplished the Leiden Index of Depression Sensitivity (LEIDS-r), Beck Depression Inventory (BDI) questionnaires after each cycle of cross-over treatment. Results: The baseline LEIDS-r in two groups did not have significant difference. After 3 weeks of treatment, patients in Group 1 had better LEIDS-r scores compared with patients in Group 2 (36.6 vs. 40.9, P = 0.012). After crossover, patients in Group 1 had worse LEIDS-r scores compared with patients in Group 2 (39.2 vs. 35.2, P = 0. 0.016). Conclusion: Probiotics have the tendency to improve cognitive reactivity to sad mood in CD patients.
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