期刊
JOURNAL OF FUNCTIONAL FOODS
卷 79, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104397
关键词
Ellagic acid; Diabetes; Nephropathy; Nrf2; Oxidative stress; Inflammation
资金
- Deanship of Scientific Research at Princess Nourah bint Abdulrahman University [RGP-1441 -0032]
The study showed that EA can improve diabetic nephropathy in rats through antioxidant and anti-inflammatory effects. In STZ-induced diabetic rats, EA prevented renal damage, oxidative stress, inflammation, and apoptosis.
This study examined if the protective effect of Ellagic acid (EA) against streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats involves activation of Nrf2. Diabetes mellitus was induced by a single i.p dose of STZ (65 mg/kg). The Rats were divided into 5 groups (n = 12/each) and treated for 8 weeks as control, control + EA (100 mg/kg), STZ, STZ + EA (100 mg/kg), and STZ + EA + trigonelline (Nrf2 inhibitor/0.2 mg/kg). EA prevented renal damage, oxidative stress, inflammation, and apoptosis. These effects were associated with reduced activity of NF-?B, upregulated GSH, ?-GCL, and SOD, and increased the nuclear translocation of Nrf2. Besides, EA suppressed the cytoplasmic expression of keap1 and its interaction with Nrf2, increased the phosphorylation of Akt and GS3K?, and reduced the phosphorylation and nuclear accumulation of Fyn. All these alterations were abolished by trigonelline. In conclusion, EA ameliorates DN in rats by antioxidant and anti-inflammatory potentials.
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