期刊
ONCOTARGETS AND THERAPY
卷 14, 期 -, 页码 1969-1980出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S298438
关键词
Musashi-2; EMT; EGF; TGF-beta; notch; Wnt; targeted therapy
资金
- Chinese National Science Foundation [81672835]
In the aggressive progression of malignant tumors, MSI2 plays a crucial role in regulating EMT and is closely associated with the EGF, TGF-beta, Notch, and Wnt pathways.
Local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. It is generally believed that this malignant behavior is stimulated by epithelial-mesenchymal transition (EMT). Musashi (MSI) RNA-binding proteins, belonging to the evolutionarily conserved RNA-binding proteins (RBP) family, were originally discovered to regulate asymmetric cell division during embryonic development. Recently, Musashi-2 (MSI2), as a key member of MSI family, has been prevalently reported to be tightly associated with the advanced clinical stage of several cancers. Multiple oncogenic signaling pathways mediated by MSI2 play vital roles in EMT. Here, we systematically reviewed the detailed role and signal networks of MSI2 in regulating cancer development, especially in EMT signal transduction, involving EGF, TGF-beta, Notch, and Wnt pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据