期刊
EUROPEAN ADDICTION RESEARCH
卷 27, 期 5, 页码 371-380出版社
KARGER
DOI: 10.1159/000514192
关键词
Methadone; Diamorphine; Buprenorphine; Quality of life; Opioid replacement therapy
资金
- Berlin Society of Psychiatry and Neurology
Research on 248 opioid-dependent patients receiving different substitution treatments revealed significant differences in physical and psychological functioning among patients, indicating potential relevance for the therapy of opioid addiction.
Background: Research on quality of life (QoL) of chronically ill patients provides an opportunity to evaluate the efficacy of long-term treatments. Although it is established that opioid replacement therapy is an effective treatment for opioid-dependent patients, there is little knowledge about physical and psychological functioning of QoL for different treatment options. Objectives: Altogether, 248 opioid-dependent patients receiving substitution treatment with either methadone/levomethadone (n = 126), diamorphine (n = 85), or buprenorphine (n = 37) were recruited in 6 German therapy centers. Methods: Sociodemographic data were collected. QoL - physical and psychological functioning - for different substitutes was assessed using the Profile of the Quality of Life in the Chronically Ill (PLC) questionnaire. Results: Patient groups were similar regarding age and duration of opioid dependence. Employment rate was significantly higher (p < 0.005, phi = 0.22) in the buprenorphine group (46%) compared to methadone (18%). Dosage adjustments were more frequent (p < 0.001, phi = 0.29) in diamorphine (55%) than in methadone (30%) or buprenorphine (19%) patients. Buprenorphine and diamorphine patients rated their physical functioning substantially higher than methadone patients (p < 0.001, eta(2) = 0.141). Diamorphine patients reported a higher psychological functioning (p < 0.001, eta(2) = 0.078) and overall life improvement (p < 0.001, eta(2) = 0.060) compared to methadone, but not compared to buprenorphine patients (both p > 0.25). Conclusion: Measurement of important QoL aspects indicates significant differences for physical and psychological functioning in patients receiving the substitutes methadone/levomethadone, diamorphine, and buprenorphine. This could be relevant for the differential therapy of opioid addiction.
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