期刊
JACC-CARDIOVASCULAR IMAGING
卷 15, 期 1, 页码 145-159出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2021.03.028
关键词
coronary artery disease; fluorescence; multimodality imaging; near-infrared spectroscopy; optical; coherence tomography
资金
- National Health and Medical Research Council (NHMRC) [APP2001646]
- Australian Research Council [CE140100003]
- Hospital Research Foundation Group 2020 translational project grant
- National Heart Foundation of Australia [102093, FLF102056]
- Netherlands Heart Institute Fellowship
- Lin Huddleston Senior Fellowship from the National Heart Foundation of Australia
- NHMRC [GNT1174098, 1111630, APP1178912, APP2002254, CDF1161506]
- AstraZeneca
- Amgen
- Anthera
- CSL Behring
- Cerenis
- Eli Lilly
- Esperion
- Resverlogix
- Novartis
- InfraReDx
- Sanofi-Regeneron
- Abbott Vascular
- National Health and Medical Research Council of Australia [1111630] Funding Source: NHMRC
This review examines emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation, aiming to advance clinical approaches for predicting atherothrombotic events and improving the treatment of coronary atherosclerosis.
The majority of coronary atherothrombotic events presenting as myocardial infarction (MI) occur as a result of plaque rupture or erosion. Understanding the evolution from a stable plaque into a life-threatening, high-risk plaque is required for advancing clinical approaches to predict atherothrombotic events, and better treat coronary atherosclerosis. Unfortunately, none of the coronary imaging approaches used in clinical practice can reliably predict which plaques will cause an MI. Currently used imaging techniques mostly identify morphological features of plaques, but are not capable of detecting essential molecular characteristics known to be important drivers of future risk. To address this challenge, engineers, scientists, and clinicians have been working hand-in-hand to advance a variety of multimodality intravascular imaging techniques, whereby 2 or more complementary modalities are integrated into the same imaging catheter. Some of these have already been tested in early clinical studies, with other next-generation techniques also in development. This review examines these emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation from both an engineering and clinical perspective. (J Am Coll Cardiol Img 2022;15:145-159) (c) 2022 by the American College of Cardiology Foundation.
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