期刊
JACC-CARDIOVASCULAR IMAGING
卷 14, 期 11, 页码 2155-2166出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2021.04.011
关键词
cardiovascular magnetic resonance; COVID-19; late gadolinium enhancement; myocardial edema; myocarditis; SARS-CoV-2; troponin
资金
- Goldman Sachs
- Citadel and Citadel Securities
- The Guy Foundation
- GW Pharmaceuticals
- Kusuma Trust
- Jagclif Charitable Trust
- UCLH Charity
- Public Health England
- UKRI UKRI-DHSC [ISRCTN58667920]
- British Heart Foundation [FS/18/83/34025]
- EACVI grant
- Rosetrees trust
- The John Black Charitable Foundation
- Medical College of St. Bartholomew's Hospital Trust
- Wellcome Trust [207511/Z/17/Z]
- NIHR Biomedical Research Funding
- BHF Intermediate Research Fellowship [FS FS/18/21/33447, FS/19/35/34374]
- University College London Hospitals (UCLH)
- Barts NIHR Biomedical Research Centres
- British Heart Foundation (BHF) Accelerator Award [AA/18/6/34223]
This study found that there was no significant difference in the occurrence of cardiovascular abnormalities between seropositive and seronegative healthy healthcare workers 6 months after mild COVID-19 infection.
OBJECTIVES The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection. BACKGROUND Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. METHODS Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21.5% (n = 157). At 6 months post-infection, 74 seropositive and 75 age-, sex-, and ethnicity-matched seronegative control subjects were recruited for cardiovascular phenotyping (comprehensive phantom-calibrated cardiovascular magnetic resonance and blood biomarkers). Analysis was blinded, using objective artificial intelligence analytics where available. RESULTS A total of 149 subjects (mean age 37 years, range 18 to 63 years, 58% women) were recruited. Seropositive infections had been mild with case definition, noncase definition, and asymptomatic disease in 45 (61%), 18 (24%), and 11 (15%), respectively, with 1 person hospitalized (for 2 days). Between seropositive and seronegative groups, there were no differences in cardiac structure (left ventricular volumes, mass, atrial area), function (ejection fraction, global longitudinal shortening, aortic distensibility), tissue characterization (T-1, T-2, extracellular volume fraction mapping, late gadolinium enhancement) or biomarkers (troponin, N-terminal pro-B-type natriuretic peptide). With abnormal defined by the 75 seronegatives (2 SDs from mean, e.g., ejection fraction <54%, septal T-1 >1,072 ms, septal T-2 >52.4 ms), individuals had abnormalities including reduced ejection fraction (n = 2, minimum 50%), T-1 elevation (n = 6), T-2 elevation (n = 9), late gadolinium enhancement (n = 13, median 1%, max 5% of myocardium), biomarker elevation (borderline troponin elevation in 4; all N-terminal pro-B-type natriuretic peptide normal). These were distributed equally between seropositive and seronegative individuals. CONCLUSIONS Cardiovascular abnormalities are no more common in seropositive versus seronegative otherwise healthy, workforce representative individuals 6 months post-mild severe acute respiratory syndrome-coronavirus-2 infection. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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