期刊
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 12, 2021
卷 12, 期 -, 页码 393-410出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-chembioeng-101220-080338
关键词
tough double network hydrogel; hydroxyapatite; artificial soft cartilage; regenerative medicine; tissue engineering
资金
- JSPS KAKENHI [JP17H06144, 17H06376]
- Grants-in-Aid for Scientific Research [17H06376] Funding Source: KAKEN
Double network hydrogels have been developed as tough materials for biomedical applications, such as regenerative medicine and artificial soft tissue engineering. Research has focused on enhancing the toughness of hydrogels based on sacrificial bond principles, as well as exploring gel-biomineral composites for early-stage osteogenesis and modeling bony sacrificial bonds.
Soft and wet hydrogels have many similarities to biological tissues, though their mechanical fragility had been one of the biggest obstacles in biomedical applications. Studies and developments in double network (DN) hydrogels have elucidated how to create tough gels universally based on sacrificial bond principles and opened a path for biomedical application of hydrogels in regenerative medicine and artificial soft connective tissues, such as cartilage, tendon, and ligament, which endure high tension and compression. This review explores a universal toughening mechanism for and biomedical studies of DN hydrogels. Moreover, because the term sacrificial bonds has been mentioned often in studies of bone tissues, consisting of biomacro-molecules and biominerals, recent studies of gel-biomineral composites to understand early-stage osteogenesis and to simulate bony sacrificial bonds are also summarized.
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