期刊
VIRUSES-BASEL
卷 13, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/v13050915
关键词
rhinovirus; wheeze; asthma; preschool children; allergy; allergen; IgE sensitization; allergen exposure; microarray
类别
资金
- European Commission's Seventh Framework Programme [260895]
- Austrian Science Fund (FWF) [P29398]
- Viravaxx AG, Vienna, Austria
- Country of Lower Austria
- Swedish Research Council
- Swedish Heart-Lung Foundation, Region Stockholm (ALF project)
- Swedish Asthma and Allergy Association's Research Foundation
- Hesselman Foundation
- King Gustaf V 80th Birthday Foundation
- Centre for Allergy Research at Karolinska Institutet
- Swedish Cancer and Allergy Foundation
- Freemason Child House Foundation in Stockholm
- Konsul Th C Bergh Foundation
- Samaritan Foundation
- Austrian Science Fund (FWF) [P29398] Funding Source: Austrian Science Fund (FWF)
Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. Increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor.
Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. The identification of such trigger factors is difficult but may have therapeutic implications. Increases of IgE and IgG in sera, were shown against allergens and the N-terminal portion of the VP1 proteins of RV species, respectively, several weeks after allergen exposure or RV infection. Hence, increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. The MeDALL-allergen chip containing comprehensive panels of allergens and the PreDicta RV chip equipped with VP1-derived peptides, representative of three genetic RV species, were used to measure allergen-specific IgE levels and RV-species-specific IgG levels in sera obtained from 120 preschool children at the time of an acute wheezing attack and convalescence. Nearly 20% of the children (22/120) showed specific IgE sensitizations to at least one of the allergen molecules on the MeDALL chip. For 87% of the children, increases in RV-specific IgG could be detected in the follow-up sera. This percentage of RV-specific IgG increases was equal in IgE-positive and -negative children. In 10% of the children, increases or de novo appearances of IgE sensitizations indicative of allergen exposure could be detected. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor. RV-induced wheezing attacks occur in IgE-sensitized and non-IgE-sensitized children, indicating that allergic sensitization is not a prerequisite for RV-induced wheeze.
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