期刊
VIRUSES-BASEL
卷 13, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/v13050732
关键词
astroviruses; tropism; gastroenteritis; encephalitis; hepatitis; respiratory disease
类别
资金
- National Institute of Allergy and Infectious Disease [K08 AI132745]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR002345]
Astroviruses were historically associated with gastrointestinal diseases in vertebrates, but now there is evidence showing their capacity to cause neurological diseases and diseases in other organ systems such as the liver, kidneys, and respiratory tract.
Astroviruses are single stranded, positive-sense RNA viruses that have been historically associated with diseases of the gastrointestinal tract of vertebrates, including humans. However, there is now a multitude of evidence demonstrating the capacity of these viruses to cause extraintestinal diseases. The most striking causal relationship is neurological diseases in humans, cattle, pigs, and other mammals, caused by astrovirus infection. Astroviruses have also been associated with disseminated infections, localized disease of the liver or kidneys, and there is increasing evidence suggesting a potential tropism to the respiratory tract. This review will discuss the current understanding of the tissue tropisms for astroviruses and their emerging capacity to cause disease in multiple organ systems.
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