4.6 Review

RON in hepatobiliary and pancreatic cancers: Pathogenesis and potential therapeutic targets

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Summary: The clinical management of primary liver cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) has significantly changed in the last 3 years due to the introduction of systemic therapies. Biomarkers play a crucial role in improving patient stratification and maximizing clinical benefits. While progress in understanding the molecular alterations of HCC is lagging, several therapeutic targets have been identified in CCA, with biomarker-driven therapies currently under evaluation in clinical trials.

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