期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 22, 期 10, 页码 757-769出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2021.1907717
关键词
Alcohol use disorder; AMPA; kainate receptor; depression; NBQX; olfactory bulbectomy; rats
类别
资金
- NIH/NIAAA [R03AA022479]
- Ministry of Education, Youth and Sports of the Czech Republic (MEYS CR) [MUNI/A/1292/2019, MUNI/A/1249/2020]
- Faculty of Medicine MU
- Masaryk University [MUNI/A/1615/2020]
Adolescent alcohol exposure can affect alcohol drinking behavior in adult rats, while the depression model does not have a significant impact. The AMPA/kainate receptor antagonist NBQX transiently reduces alcohol intake in rats with olfactory bulbectomy. Further exploration of AMPA and/or kainate receptor antagonists in co-morbid alcoholism-depression is warranted based on these results.
Objective Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others. Methods This study investigated the effects of voluntary alcohol intake during adolescence, i.e. continuous 10% alcohol access between postnatal days (PND) 29 to 43 and olfactory bulbectomy (OBX) model of depression (performed on PND 59) on alcohol drinking in Wistar rats during adulthood (PND 80-120, intermittent 20% alcohol access). In addition, the effect of NBQX, an AMPA/kainate receptor antagonist (5 mg/kg, IP) on spontaneous alcohol consumption was examined. Results Rats exposed to 10% alcohol during adolescence exhibited a lower 20% alcohol intake in the intermittent paradigm during adulthood, while the OBX-induced phenotype did not exert a significant effect on the drinking behaviour. NBQX exerted a transient reduction on alcohol intake in the OBX rats. Conclusions Our results indicate that exposure to alcohol during adolescence can affect alcohol drinking in adulthood and that further exploration of AMPA and/or kainate receptor antagonists in co-morbid alcoholism-depression is warranted.
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