期刊
VECTOR-BORNE AND ZOONOTIC DISEASES
卷 21, 期 6, 页码 413-421出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vbz.2020.2729
关键词
vector-borne disease; infectious disease; cat; epidemiology; ddPCR; cat scratch disease
资金
- National Center for Advancing Translational Sciences (NCATS), National Institutes of Health [UL1TR002489]
- Comparative Medicine and Translational Research Program of the National Institutes of Health [T32OD011130]
- North Carolina State University College of Veterinary Medicine Bartonella/Vector Borne Disease Research Foundation Fund
In this study, it was found that individuals with central nervous system symptoms were more likely to have Bartonella spp. DNA in their bloodstream compared to healthy volunteers. However, there was no significant difference in the severity of schizophrenia/schizoaffective disorder symptoms between individuals with and without evidence of Bartonella spp. infection.
Recently, infections with emerging zoonotic bacteria of the genus Bartonella have been reported in association with a range of central nervous system (CNS) symptoms. Currently, it remains unknown if Bartonella spp. infection is associated with symptoms of schizophrenia/schizoaffective disorder (SCZ/SAD). The objective of this study was to determine if there is an association between Bartonella species infection and SCZ/SAD. A secondary objective was to determine if SCZ/SAD symptoms were more severe among participants with documented Bartonella spp. infection. Using a case-control study design, 17 cases and 13 controls were evaluated with a series of clinical and cognitive assessments. Blood samples were collected and tested for Bartonella spp. infection using serological, microbiological, and molecular techniques. People with SCZ/SAD were more likely than healthy volunteers to have Bartonella spp. DNA in their bloodstream, with 11 of 17 cases (65%) positive by Bartonella spp. droplet digital PCR (ddPCR). In comparison, only one healthy volunteer was Bartonella spp. ddPCR positive (8%, p = 0.0024). Based on serology, Bartonella spp. exposure was common among people with SCZ/SAD (12 of 17) as well as among healthy volunteers (12 of 13), with no significant difference between the groups (p = 0.196). Within the case group of people with SCZ/SAD, there was no significant difference in SCZ/SAD severity scores between people with and without ddPCR evidence of Bartonella spp. infection. This pilot study provides preliminary evidence in support of future investigations that should examine a potential contribution of Bartonella spp. infection to SCZ/SAD.
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