期刊
TRENDS IN GENETICS
卷 37, 期 8, 页码 699-710出版社
CELL PRESS
DOI: 10.1016/j.tig.2021.04.010
关键词
-
资金
- Technical University of Munich Institute for Advanced Study - German Excellent Initiative
- European Seventh Framework Programme [291763]
- National Institutes of Health [R01GM134682]
In plants, stochastic gains and losses of DNA methylation at CG dinucleotides occur frequently, with a rate 100 000 times higher than genetic mutation rate. These epimutations are effectively neutral at the genome-wide scale and are stably inherited.
Stochastic gains and losses of DNA methylation at CG dinucleotides are a frequent occurrence in plants. These spontaneous 'epimutations' occur at a rate that is 100 000 times higher than the genetic mutation rate, are effectively neutral at the genome-wide scale, and are stably inherited across mitotic and meiotic cell divisions. Mathematical models have been extraordinarily successful at describing how epimutations accumulate in plant genomes over time, making this process one of the most predictable epigenetic phenomena to date. Here, we propose that their high rate and effective neutrality make epimutations a powerful new molecular clock for timing evolutionary events of the recent past and for age dating of long-lived perennials such as trees.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据