Genetics in Drug Discovery

Drug discovery is a complex process with high attrition rate: only about half of the compounds in advanced preclinical stages actually enter human trials. Key to these failures is our lack of understanding of human biology and the difficulties in translating our preclinical knowledge into cures. Here, we examine how genetics can be leveraged in drug discovery to understand and alter human biology.

Automated summary

Drug discovery is a complex process with high attrition rate, mainly due to our lack of understanding of human biology and difficulties in translating preclinical knowledge into cures. Genetics can play a key role in leveraging drug discovery to understand and alter human biology.