期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 32, 期 8, 页码 566-578出版社
CELL PRESS
DOI: 10.1016/j.tem.2021.04.001
关键词
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资金
- Australian Research Council Discovery Project [DP180101974]
- National Health and Medical Research Council [GNT1197277, GNT1117148]
- DHB Foundation, Equity Trustees
- Victorian Government
- Operational Infrastructure Support Grant
Unhealthy lifestyles and mental health problems are increasingly prevalent globally, with diet playing a significant role in influencing offspring brain development and behavior, potentially predisposing children to mental health issues. Evidence suggests that parental diet can program infant metabolism and neurobehavioral function, with implications for mental health and resilience. Additionally, the microbiota-gut-brain axis has been identified as a key mediator of host physiology, highlighting the impact of parental lineage on offspring gut health and neurobiology.
Unhealthy lifestyles and mental health problems are increasingly prevalent globally. Not only are 'junk food'-induced overweight and obesity risk factors for the development of brain disorders but they are also associated intergenerationally with ill health. Here, we reflect on the current knowledge of how maternal and paternal diet influences offspring brain development and behaviour, potentially predisposing children to mental health problems. Mounting evidence indicates diet-induced maternal and paternal programming of infant metabolism and neurobehavioural function, with potential downstream effects on mental health and resilience. Beyond the central nervous system (CNS), the microbiota-gut-brain axis has emerged as an important mediator of host physiology. We discuss how intergenerational seeding of the gut microbiome via parental lineage can influence offspring gut health and neurobiology.
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