期刊
TRENDS IN CELL BIOLOGY
卷 31, 期 9, 页码 760-773出版社
CELL PRESS
DOI: 10.1016/j.tcb.2021.03.005
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资金
- National Institutes of Health [RO1 GM122893]
Cohesin, originally known for tethering replicated sister chromatids, has now been recognized as a key regulator of gene expression. Recent studies show that cohesin plays a crucial role in regulating dynamic chromatin interactions linked to transcription control, contributing to the heterogeneity of chromatin contacts. Different cohesin subcomplexes control gene expression across the cell cycle and during developmental cell commitment.
Beyond its originally discovered role tethering replicated sister chromatids, cohesin has emerged as a master regulator of gene expression. Recent advances in chromatin topology resolution and single-cell studies have revealed that cohesin has a pivotal role regulating highly dynamic chromatin interactions linked to transcription control. The dynamic association of cohesin with chromatin and its capacity to perform loop extrusion contribute to the heterogeneity of chromatin contacts. Additionally, different cohesin subcomplexes, with specific properties and regulation, control gene expression across the cell cycle and during develop-mental cell commitment. Here, we discuss the most recent literature in the field to highlight the role of cohesin in gene expression regulation during transcriptional shifts and its relationship with human diseases.
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