期刊
TRENDS IN CELL BIOLOGY
卷 31, 期 5, 页码 372-386出版社
CELL PRESS
DOI: 10.1016/j.tcb.2021.01.001
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资金
- F.R.S.-F.N.R.S. [EOS 0019118FRG36]
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
- Fondation Simone et Pierre Clerdent
- Belgian Science Policy (IAP-VII network) [P7/20]
- ERANET Neuron STEM-MCD and NeuroTalk
Axonal microtubules support long-distance transport of cargoes, with local translation generating axonal protein foci for maintaining network integrity and modulating motor function to ensure proper cargo trafficking along microtubules.
The axonal microtubules (MTs) support long-distance transport of cargoes that are dispatched to distinct cellular subcompartments. Among them, mRNAs are directly transported in membraneless ribonucleoprotein (RNP) granules that, together with ribosomes, can also hitchhike on fast-moving membrane-bound organelles for accurate transport along MTs. These organelles serve as platforms for mRNA translation, thus generating axonal foci of newly synthesized proteins. Local translation along axons not only supports MT network integrity but also modulates the processivity and function of molecular motors to allow proper trafficking of cargoes along MTs. Thus, identifying the mechanisms that coordinate axonal transport with local protein synthesis will shed new light on the processes underlying axon development and maintenance, whose deregulation often contribute to neurological disorders.
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