Importance of clonal hematopoiesis in heart failure

Heart failure is prevalent in the elderly population. Inflammatory processes can contribute to the progression of heart failure by altering the balance of tissue healing and pathological remodeling during the injury response. New findings show that aging can alter immune cell phenotypes through the process of clonal hematopoiesis. This condition results from acquired somatic DNA mutations in specific driver genes that give rise to clonal expansions of mutant hematopoietic cells with overactive inflammatory properties. Recent clinical and experimental studies have shown that clonal hematopoiesis is prevalent in heart failure patients and associated with poor prognosis. In this review, we summarize current evidence that associates clonal hematopoiesis with the progression of heart failure. We further describe the mechanistic links between clonal hematopoiesis and the pro-inflammatory responses that can contribute to pathological outcomes in the heart. Finally, we provide perspectives on future research directions in the area of clonal hematopoiesis and heart failure. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

Heart failure is common in the elderly, and inflammatory processes and clonal hematopoiesis may be involved in its progression by altering tissue healing and pathological remodeling. These processes contribute to the overactivity of inflammatory properties and lead to poor prognosis in heart failure patients.