Reductive Glycine Pathway: A Versatile Route for One-Carbon Biotech

Hong et al. heterologously expressed the metabolic core of the reductive glycine pathway (rGlyP) as a sink for the anaerobic conversion of glycerol. This recent study concludes several reports in 2020 on the ATP-efficient, one-carbon-assimilating rGlyP. Its engineering in diverse hosts could help the transformation toward renewable, one-carbon-based bioproduction.

Automated summary

The study by Hong et al. demonstrates that expressing the metabolic core of rGlyP heterologously can act as a sink for anaerobic conversion of glycerol, which is an efficient one-carbon assimilating pathway. Engineering this pathway in diverse hosts could facilitate the transition towards renewable, one-carbon-based bioproduction.