Application of enantioselective separation techniques to bioanalysis of chiral drugs and their metabolites

Separations of enantiomers are performed for very different purposes. Although the basic approach to separate enantiomers can be quite general, there may be significant differences in method refinement based on the final application. This short overview deals with the specific requirements that the bioanalytical applications pose to the enantioseparation methods, compares various separation methods from the viewpoint of their suitability and potential for bioanalytical purposes and discusses current developments, unresolved problems and future trends in this field. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Separation of enantiomers serves different purposes, with variations in method refinement based on the final application. This overview focuses on the specific requirements of bioanalytical applications, comparing different separation methods and discussing current developments and future trends in the field.