Sulfated polyborate: A dual catalyst for the reductive amination of aldehydes and ketones by NaBH4

An efficient, quick, and environment-friendly one-pot reductive amination of aldehydes or ketones was developed. In ethanol at 70 degrees C, a imination catalyzed by sulfated polyborate and further reduced by sodium borohydride yields various amines. The present method has many significant benefits, including a shorter reaction time, excellent yields, and a hassle-free, straightforward experimental process. The reaction has a wide range of applications due to its flexibility, including secondary amine for reductive amination. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An efficient one-pot reductive amination of aldehydes or ketones catalyzed by sulfated polyborate and further reduced by sodium borohydride is developed. The method offers benefits such as shorter reaction time, excellent yields, and a hassle-free experimental process, making it suitable for a wide range of applications, including secondary amine for reductive amination.