4.4 Article

Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

期刊

TETRAHEDRON LETTERS
卷 74, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.153176

关键词

Antioxidant; Biaryl dimer; Natural product; Dihydroisocoumarin

资金

  1. JSPS KAKENHI [20K09396, 19H02851]
  2. Uehara Memorial Foundation
  3. Takeda Science Foundation
  4. Tokushima University [1803003, 1802001]
  5. Grants-in-Aid for Scientific Research [20K09396, 19H02851] Funding Source: KAKEN

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In this study, a biaryl dimer based on eurotiumide A was synthesized, showing potent antioxidant activities without cytotoxicity against murine colon and human myeloma cells.
A biaryl dimer based on eurotiumide A, a dihydroisocoumarin-type natural product possessing a 1,4-hydroquinone skeleton, was synthesized herein. The radical scavenging activity and cytotoxicity were evaluated. The prepared biaryl dimer and eurotiumide A displayed comparable potent antioxidant activities to those of alpha-tocopherol and edaravone. However, the biaryl dimer did not show any cytotoxicity against murine colon and human myeloma cells. (C) 2021 Elsevier Ltd. All rights reserved.

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