Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

A biaryl dimer based on eurotiumide A, a dihydroisocoumarin-type natural product possessing a 1,4-hydroquinone skeleton, was synthesized herein. The radical scavenging activity and cytotoxicity were evaluated. The prepared biaryl dimer and eurotiumide A displayed comparable potent antioxidant activities to those of alpha-tocopherol and edaravone. However, the biaryl dimer did not show any cytotoxicity against murine colon and human myeloma cells. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

In this study, a biaryl dimer based on eurotiumide A was synthesized, showing potent antioxidant activities without cytotoxicity against murine colon and human myeloma cells.