C2-arylacylation of 2H-benzothiazoles with methyl arenes via Selectfluor oxidation

An efficient Selectfluor-oxidative protocol was developed for the direct C2-arylacylation of 2H-benzothiazoles via the radical reaction of 2H-benzothiazoles with methyl arenes. Selectfluor can effectively promote the oxidative cross-coupling without an external catalyst. This arylacylation reaction tolerates a wide range of functional groups affording 28 examples of the arylacylated products in 39-81% yield. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An efficient Selectfluor-oxidative protocol was developed for the direct C2-arylacylation of 2H-benzothiazoles via radical reaction. The reaction tolerates a wide range of functional groups, providing 28 examples of arylacylated products in yields ranging from 39% to 81%.