期刊
SYNTHETIC COMMUNICATIONS
卷 51, 期 13, 页码 1963-1973出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2021.1913606
关键词
Baker’ s yeast; tetrahydrobenzo[a]xanthene-11-ones; pyrazolo[3; 4-b]quinolines; one-pot synthesis; multicomponent
Novel synthetic routes utilizing water and baker's yeast catalysis at room temperature have been developed for efficient multicomponent cyclocondensations, yielding bioactive tetrahydrobenzo[a]xanthene-11-ones and pyrazolo[3,4-b]quinolines. The protocols are cost-effective, operationally efficient, and environmentally friendly, making them a promising alternative to existing methods.
Water mediated and baker's yeast catalyzed, efficient synthetic routes have been first time developed for multicomponent cyclocondensations leading to bioactive tetrahydrobenzo[a]xanthene-11-ones (4a-h) and pyrazolo[3,4-b]quinolines (7a-i). The developed protocols are conducted at room temperature and gave better to excellent yields of the titled compounds. The biocatalytical resource, activated baker's yeast is readily available, and biodegradable. These protocols are more convenient, scalable, and obey most of the green principles also. The developed protocols are cost effective and better in operation than existing ones.
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