期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 785, 期 -, 页码 36-43出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2015.03.094
关键词
Omega 3 polyunsaturated fatty acid; GPR120; Macrophage; Anti-inflammation; FFA4
资金
- Korean National Research Foundation - Korean Government (MSIP) [2009-0083538]
- National Research Foundation of Korea [2009-0083538, 22A20130012283] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are plentiful in fish oil, have been known for decades to be beneficial functional nutrients in different disease states. GPR120 is a G protein-coupled receptor for long-chain unsaturated fatty acids, including n-3 PUFAs, and was recently renamed free fatty acid receptor 4 (FFA4). Studies on FFA4-deficient mice and the development of specific pharmacological tools have started to unravel the functions of FFA4 associated with the actions of n-3 PUFAs in obesity, type 2 diabetes, and inflammation-related diseases. Here, the state of the art regarding the roles and functions of FFA4 and n-3 PUFA in macrophages are reviewed from the pharmacological perspective. In particular, the functions of n-3 PUFA on the anti-inflammatory M2 phenotypes of macrophages in different organs, such as, adipose tissues and liver, are discussed along with future research directions. (C) 2015 Elsevier B.V. All rights reserved.
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