Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

A one pot synthesis of beta-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for beta-ketonitriles.

Automated summary

A one-pot synthesis of beta-ketonitriles from 3-chloropropenals using benign reagents such as iodine, aqueous ammonia, and sodium hydroxide has been described. This approach is convenient, inexpensive, non-toxic, and eco-friendly.