期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 789, 期 -, 页码 229-243出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2016.07.046
关键词
Pterostilbene; Cardiovascular disease; NF-kappa B; AMPK; HO-1; Nrf2
资金
- Indian Institute of Technology (Banaras Hindu University), Varanasi - Ministry of Human Resource Development, Government of India
Pterostilbene (PS) is a well-recognized antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. Interest in this compound has been renewed in recent years, and studies have found that PS possesses an array of pharmacological properties, including chemopreventive, anti-inflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. However, the greater in vivo bioavailability of PS, as compared to resveratrol, is an added advantage for its efficacy. This review provides a summary regarding the sources, pharmacokinetic aspects and pharmacodynamics of PS, with a focus on the molecular mechanisms underlying its protective effects against cancer, brain injuries and heart disease. Studies regarding the safety profile of PS have also been included. Based on the presently available evidence, we conclude that PS represents an active phytonutrient and a potential drug with pleiotropic health applications. (C) 2016 Elsevier B.V. All rights reserved.
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