期刊
SYNTHESIS-STUTTGART
卷 53, 期 17, 页码 3037-3044出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1467-2494
关键词
C-O bond activation; cross-coupling; nickel; natural product; late-stage functionalization
资金
- SEEDS program from Osaka University
This nickel-catalyzed cross-coupling reaction allows for the selective monosubstitution of one methoxy group in buflavine, leading to the formation of various derivatives by introducing different groups into the molecule.
The nickel-catalyzed cross-coupling of methoxyarenes was applied to buflavine, which allows for the selective monosubstitution of one of the two methoxy groups in the molecule, leading to the formation of 2- and 3-substituted isomers. Trimethylsilylmethyl (TMSCH2), phenyl, and alkynyl groups can be introduced into buflavine using this method. The resulting TMSCH2 analogue of buflavine can also be converted into several other derivatives.
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