期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 778, 期 -, 页码 84-89出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2015.03.087
关键词
Mast cell; T reg cells; T effector cells; B cells; B reg cells
资金
- COST Action Mast cells and Basophils: targets for innovative therapies [BM1007]
- Italian Ministry of Health
- Ministero dell'Istruzione, Universita e Ricerca
- ASIMAS (ASsociazione Italiana MAStocitosi)
- Tel Aviv University
- Allergists for Israel
- Israel Science Foundation [1061/09]
- [15561]
- [11843]
A diversity of immune mechanisms have evolved to protect normal tissues from infection, but from immune damage too. Innate cells, as well as adaptive cells, are critical contributors to the correct development of the immune response and of tissue homeostasis. There is a dynamic cross-talk between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage as well as the development of the immune response. Mast cells have shown a great plasticity, modifying their behavior at different stages of immune response through interaction with effector and regulatory populations of adaptive immunity. Understanding the interplays among T effectors, regulatory T cells, B cells and regulatory B cells with mast cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immune-modulator and-suppressor elements in the innate and adaptive immune system. (C) 2015 Elsevier B.V. All rights reserved.
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