4.4 Article

Photoredox-Enabled Decarboxylative Synthesis of Unnatural α-Amino Acids

期刊

SYNLETT
卷 33, 期 2, 页码 109-115

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/a-1499-8679

关键词

amino acids; decarboxylation; photoredox catalysis; radicals

资金

  1. Svenska Forskningsradet Formas [201901269]
  2. Vetenskapsradet (Swedish Research Council) [202004764]
  3. Magnus Bergvalls Stiftelse (Magnus Bergvall foundation)
  4. Kungliga Tekniska Hogskolan (KTH Royal Institute of Technology)
  5. Olle Engkvist Foundation

向作者/读者索取更多资源

Recent progress has been made in accessing unnatural alpha-amino acids through photoredox-mediated synthetic methods with a focus on various decarboxylative radical-based strategies.
Recently, development of general synthetic routes to unnatural alpha-amino acids has gained significant momentum, driven by the high demand for such building blocks in fundamental research within molecular and structural biology, as well as for development of new pharmaceuticals. Herein, we highlight the recent progress in employing photoredox-mediated synthetic methods for accessing unnatural alpha-amino acids with a focus on various decarboxylative radical-based strategies.

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