Copper-Catalyzed Synthesis of β- and δ-Carbolines by Double N-Arylation of Primary Amines

Two efficient and practical approaches are reported for the synthesis of beta- and delta-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C-N coupling reactions and subsequent annulations by twofold Pd-catalyzed C-N coupling with amines.

Automated summary

Two efficient methods for synthesizing beta- and delta-carbolines from 3,4-dibromopyridine are reported, involving Cu-catalyzed double C-N coupling reactions and subsequent Pd-catalyzed C-N coupling with amines.